|
||
Otolaryngology, ENT & Sinus News Provided by the California Sinus CentersAdenoid cystic carcinoma of the head and neck - Corrected ProofJanuary 6, 2012, 12:00 pm by American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in PressAbstract: Purpose: To report our experience using radiotherapy alone or combined with surgery to treat adenoid cystic carcinoma of the head and neck.Materials and methods: Radiotherapy alone or combined with surgery was used to treat 120 previously untreated patients with adenoid cystic carcinoma (ACC) of the head and neck from August 1966 to March 2008. Patients were treated with curative intent. American Joint Committee on Cancer stage distribution was,T0 (n = 1), T1 (n = 26), T2 (n = 25), T3 (n = 14), T4 (n = 54), N0 (n = 113), N1 (n = 2), N2a (n = 1), N2b (n = 2), and N2c (n = 2). Treatment included surgery with postoperative radiotherapy (n = 71), radiotherapy alone (n = 46), and preoperative radiotherapy and surgery (n = 3). Incidental and clinical perineural invasion was found in 41 (34%) and 35 (29%) patients, respectively. Median follow-up was 8.6 and 11.6 years overall and among living patients, respectively.Results: The10-year overall, cause-specific, and distant metastasis-free survival rates, respectively, were as follows: radiotherapy alone, 37%, 46%, and 76%; surgery and radiotherapy, 57%, 71%, and 62%; and overall, 50%. The10-year local control rates were as follows: radiotherapy alone, 36%; surgery and radiotherapy, 84%; and overall, 65%. The 10-year neck control rates were as follows: elective nodal irradiation (ENI), 98%; no ENI, 89%; and overall, 95%.Conclusions: Surgery and adjuvant radiotherapy offer the best chance for cure for patients with resectable adenoid cystic carcinomas of the head and neck. Some patients with advanced, incompletely resectable disease can be cured with radiotherapy alone. ENI should be considered for primary sites located in lymphatic-rich regions.
More from American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press Ototoxicity of Burow solution on the guinea pig cochlea - Corrected Proof American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: May 7, 2012, 12:00 pm Abstract: Purpose of the study: The aim of the present study was to evaluate the ototoxicity of Burow solution.Procedures: Compound action potentials (CAPs) of the eighth nerve were measured before and 30 Vocal characteristics in patients with thyroiditis - Corrected Proof American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: May 7, 2012, 12:00 pm Abstract: Objective: The aim of the present study was to describe the vocal characteristics of patients with thyroiditis in a clinical setting.Materials and methods: A total of 17 consecutive patients with the Bilateral enlarged vestibular aqueduct with associated bilateral Mondini dysplasia - Corrected Proof American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: April 26, 2012, 12:00 pm Abstract: Enlarged Vestibular Aqueduct (EVA) and Mondini's dysplasia ( incomplete partitioning type II) are entitites that have been fairly well described in the literature as potential causes of hearing loss in the Pattern of expression of cyclooxygenase-2 in malignant transformation of sinonasal inverted papilloma - Corrected Proof American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: April 26, 2012, 12:00 pm Abstract: Objective: Cyclooxygenases (COXs) are enzymes that catalyze the conversion of arachidonic acid to prostaglandins. Many studies have suggested that COX-2, the inducible form of COX, is important in carcinogenesis. However, little Etiology of unilateral hearing loss in a national hereditary deafness repository - Corrected Proof American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: April 26, 2012, 12:00 pm Abstract: Purpose: The aim of this study was to characterize the genetic, audiologic, and epidemiologic characteristics of unilateral hearing loss (HL) in a national hereditary deafness repository.Materials and Methods: This is a
|
