Patient Testimonials

ENT Research at the California Sinus Centers

 

Otolaryngology, ENT & Sinus News Provided by the California Sinus Centers

Pattern of expression of cyclooxygenase-2 in malignant transformation of sinonasal inverted papilloma - Corrected Proof

April 26, 2012, 12:00 pm by American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press

Abstract: Objective: Cyclooxygenases (COXs) are enzymes that catalyze the conversion of arachidonic acid to prostaglandins. Many studies have suggested that COX-2, the inducible form of COX, is important in carcinogenesis. However, little is known about the pattern of expression of COX-2 in a multistep process of malignant transformation of sinonasal inverted papilloma (IP). In this study, we investigated COX-2 expression in IPs, IPs with dysplasia, IPs with squamous cell carcinoma (SCC), and primary SCCs of sinonasal tract.Study design: A retrospective study was conducted.Setting: The setting was a tertiary care referral center.Subjects and methods: The expression of COX-2 was evaluated by immunohistochemistry in 56, 7, 18, and 17 cases of IPs, IPs with dysplasia, IPs with SCC, and primary SCCs, respectively. Furthermore, we investigated the possible correlation between the expression of COX-2 and clinicopathologic variables in patients with IPs with SCC and primary SCC patients.Results: Positive immunoreactivity for COX-2 was observed in 3 (5.4%) of 56 IPs, 7 (38.9%) of 18 IPs with SCC, and 7 (41.2%) of 17 primary SCCs, whereas it was not observed in IPs with dysplasia. The percentage of tumors with COX-2–positive immunostaining was significantly higher in IPs with SCC and primary SCCs compared with benign IPs. There was no significant correlation between the expression of COX-2 and clinicopathologic variables, such as tumor stage, histologic differentiation, and the proportion of malignant areas in patients with IPs with SCC.Conclusion: Cyclooxygenase-2 may play an important role in the process of malignant transformation from IP to SCC.

Read the full article


More from American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press

An Unusual Presentation of NK/T-Cell Lymphoma, Nasal-Type in the United States
American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: July 24, 2014, 12:00 pm


MRI criteria for the diagnosis of pleomorphic adenoma: a validation study
American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: July 22, 2014, 12:00 pm


Subtotal supracricoid laryngectomy: changing in indications, surgical techniques and use of new surgical devices
American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: July 21, 2014, 12:00 pm


Rare Embryonal Rhabdomyosarcoma of External Acoustic Canal: A Case Report And Literature Review
American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: July 21, 2014, 12:00 pm


Long-term efficacy of inferior meatal antrostomy for treatment of postoperative maxillary mucoceles
American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: July 21, 2014, 12:00 pm


 

NOTICE: The CSC web site "Otolaryngology ENT Industry News" has data and links presented by way of the above mentioned RSS news feeds. We offer this industry news for your convenience and education. CSC does not review the information provided in this section. CSC does not assume any endorsement or present these third-party feeds and links as CSC belief or in conjunction with CSC whatsoever. While we try to select appropriate feeds to prevent objectionable content from being displayed, the presence of any article does not indicate endorsement or recommendation by the California Sinus Centers. For more information, please see our disclaimer.