Patient Testimonials

ENT Research at the California Sinus Centers

 

Otolaryngology, ENT & Sinus News Provided by the California Sinus Centers

Pattern of expression of cyclooxygenase-2 in malignant transformation of sinonasal inverted papilloma - Corrected Proof

April 26, 2012, 12:00 pm by American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press

Abstract: Objective: Cyclooxygenases (COXs) are enzymes that catalyze the conversion of arachidonic acid to prostaglandins. Many studies have suggested that COX-2, the inducible form of COX, is important in carcinogenesis. However, little is known about the pattern of expression of COX-2 in a multistep process of malignant transformation of sinonasal inverted papilloma (IP). In this study, we investigated COX-2 expression in IPs, IPs with dysplasia, IPs with squamous cell carcinoma (SCC), and primary SCCs of sinonasal tract.Study design: A retrospective study was conducted.Setting: The setting was a tertiary care referral center.Subjects and methods: The expression of COX-2 was evaluated by immunohistochemistry in 56, 7, 18, and 17 cases of IPs, IPs with dysplasia, IPs with SCC, and primary SCCs, respectively. Furthermore, we investigated the possible correlation between the expression of COX-2 and clinicopathologic variables in patients with IPs with SCC and primary SCC patients.Results: Positive immunoreactivity for COX-2 was observed in 3 (5.4%) of 56 IPs, 7 (38.9%) of 18 IPs with SCC, and 7 (41.2%) of 17 primary SCCs, whereas it was not observed in IPs with dysplasia. The percentage of tumors with COX-2–positive immunostaining was significantly higher in IPs with SCC and primary SCCs compared with benign IPs. There was no significant correlation between the expression of COX-2 and clinicopathologic variables, such as tumor stage, histologic differentiation, and the proportion of malignant areas in patients with IPs with SCC.Conclusion: Cyclooxygenase-2 may play an important role in the process of malignant transformation from IP to SCC.

Read the full article


More from American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press

Recovery of Hearing in Meniere’s Disease after Antiviral Treatment - Accepted Manuscript
American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: April 7, 2014, 12:00 pm
Abstract: Objective: Determine the outcome of hearing in Meniere’s Disease (MD) after antiviral treatment.Study Design: Prospective study.Setting: University Hospital.Methods: Thirty one new patients with a diagnosis of MD were treated with antiviral

Complete response to weekly carboplatin-docetaxel chemotherapy in a 91-years old woman with anaplastic thyroid cancer - Accepted Manuscript
American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: March 31, 2014, 12:00 pm
Abstract: Anaplastic Thyroid Cancer (ATC) is an unusual tumour with the worst prognosis among thyroid malignancies. Treatment of the patients diagnosed with ATC is not standardized and the feasible options include surgery,

Amniotic Membrane in Reconstraction of larynx Following Chondro sarcoma Resection: a case report - Accepted Manuscript
American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: March 28, 2014, 12:00 pm
Abstract: Chondrosarcomas of the larynx are rare malignancies and frequently located in cricoid cartilage. They are characterized by a low tendency to metastasis (low grade type). The treatment of choice is surgery,

Mini-invasive Boomerang-Plasty for Aesthetic Restoration of Lower Third Face Aging. Mini Boomerang-Plasty to Lower Face Lift - Accepted Manuscript
American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: March 28, 2014, 12:00 pm
Abstract: Introduction: There is an increased demand to improve facial appearance and preserve a youthful appearance for as long as possible. Minimally invasive facial procedures have boomed among young patients with less

Commentary on “How to avoid mucocele formation under pedicled nasoseptal flap” - Accepted Manuscript
American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: March 28, 2014, 12:00 pm
We read with great interest the letter by Karligkiotis et al. which characterizes techniques for avoiding mucocele formation following skull base reconstruction with pedicled nasoseptal flaps. This letter was in response

 

NOTICE: The CSC web site "Otolaryngology ENT Industry News" has data and links presented by way of the above mentioned RSS news feeds. We offer this industry news for your convenience and education. CSC does not review the information provided in this section. CSC does not assume any endorsement or present these third-party feeds and links as CSC belief or in conjunction with CSC whatsoever. While we try to select appropriate feeds to prevent objectionable content from being displayed, the presence of any article does not indicate endorsement or recommendation by the California Sinus Centers. For more information, please see our disclaimer.