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Otolaryngology, ENT & Sinus News Provided by the California Sinus CentersSkin carcinoma of the head and neck with perineural invasion - Corrected ProofDecember 21, 2011, 12:00 pm by American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in PressAbstract: Purpose: The aim of the study was to update the experience treating cutaneous squamous cell and basal cell carcinomas of the head and neck with incidental or clinical perineural invasion (PNI) with radiotherapy (RT).Materials and methods: From 1965 to 2007, 216 patients received RT alone or with surgery and/or chemotherapy.Results: The 5-year overall, cause-specific, and disease-free survivals for incidental and clinical PNIs were 55% vs 54%, 73% vs 64%, and 67% vs 51%. The 5-year local control, local-regional control, and freedom from distant metastases for incidental and clinical PNIs were 80% vs 54%, 70% vs 51%, and 90% vs 94%. On univariate and multivariate (P = .0038 and .0047) analyses, clinical PNI was a poor prognostic factor for local control. The rates of grade 3 or higher complication in the incidental and clinical PNI groups were 16% and 36%, respectively.Conclusions: Radiotherapy plays a critical role in the treatment of this disease. Clinical PNI should be adequately irradiated to include the involved nerves to the skull base.
More from American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press Ototoxicity of Burow solution on the guinea pig cochlea - Corrected Proof American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: May 7, 2012, 12:00 pm Abstract: Purpose of the study: The aim of the present study was to evaluate the ototoxicity of Burow solution.Procedures: Compound action potentials (CAPs) of the eighth nerve were measured before and 30 Vocal characteristics in patients with thyroiditis - Corrected Proof American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: May 7, 2012, 12:00 pm Abstract: Objective: The aim of the present study was to describe the vocal characteristics of patients with thyroiditis in a clinical setting.Materials and methods: A total of 17 consecutive patients with the Bilateral enlarged vestibular aqueduct with associated bilateral Mondini dysplasia - Corrected Proof American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: April 26, 2012, 12:00 pm Abstract: Enlarged Vestibular Aqueduct (EVA) and Mondini's dysplasia ( incomplete partitioning type II) are entitites that have been fairly well described in the literature as potential causes of hearing loss in the Pattern of expression of cyclooxygenase-2 in malignant transformation of sinonasal inverted papilloma - Corrected Proof American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: April 26, 2012, 12:00 pm Abstract: Objective: Cyclooxygenases (COXs) are enzymes that catalyze the conversion of arachidonic acid to prostaglandins. Many studies have suggested that COX-2, the inducible form of COX, is important in carcinogenesis. However, little Etiology of unilateral hearing loss in a national hereditary deafness repository - Corrected Proof American Journal of Otolaryngology - Head and Neck Medicine and Surgery - Articles in Press: April 26, 2012, 12:00 pm Abstract: Purpose: The aim of this study was to characterize the genetic, audiologic, and epidemiologic characteristics of unilateral hearing loss (HL) in a national hereditary deafness repository.Materials and Methods: This is a
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