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Otolaryngology, ENT & Sinus News Provided by the California Sinus CentersTime-Resolved Fluorescence Spectroscopy as a Diagnostic Technique of Oral Carcinoma: Validation in the Hamster Buccal Pouch Model [Original Article]February 1, 2010, 12:00 pm by Archives of Otolaryngology Head & Neck SurgeryObjective To investigate the benefit of using time-resolved, laser-induced fluorescence spectroscopy for diagnosing malignant and premalignant lesions of the oral cavity. Design The carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) was applied to 1 cheek pouch of 19 hamsters. The contralateral pouch and the cheek pouches of 3 hamsters without DMBA exposure served as controls. Setting University of California, Davis. Participants Twenty-two golden/Syrian hamsters. Intervention A nitrogen pulse laser was used to induce tissue autofluorescence between the wavelengths of 360 and 650 nm. Main Outcome Measures Spectral intensities and time-domain measurements were obtained and compared with the histopathologic findings at each corresponding site. Results Spectral intensities and lifetime values at 3 spectral bands (SBs; SB1 = 380 ± 10 nm; SB2 = 460 ± 10 nm, and SB3 = 635 ± 10 nm) allowed for discrimination among healthy epithelium, dysplasia, carcinoma in situ, and invasive carcinoma. The lifetime values at SB2 were the most important when distinguishing the lesions using only time-resolved parameters. An algorithm combining spectral fluorescence parameters derived from both spectral and time-domain parameters (peak intensities, average fluorescence lifetimes, and the Laguerre coefficient [zero-order]) for healthy epithelium, dysplasia, carcinoma in situ, and invasive carcinoma provided the best diagnostic discrimination, with 100%, 100%, 69.2%, and 76.5% sensitivity and 100%, 92.2%, 97.1%, and 96.2% specificity, respectively. Conclusions The addition of time-resolved fluorescence-derived parameters significantly improves the capability of fluorescence spectroscopy–based diagnostics in the hamster buccal pouch. This technique provides a potential noninvasive diagnostic instrument for head and neck cancer.
More from Archives of Otolaryngology Head & Neck Surgery Long-term Results of Radiofrequency Turbinoplasty for Allergic Rhinitis Refractory to Medical Therapy [Original Article] Archives of Otolaryngology Head & Neck Surgery: July 19, 2010, 12:00 pm Objective To study the long-term outcomes of radiofrequency (RF) turbinate surgery for the treatment of allergic rhinitis refractory to medical therapy.Design A retrospective review of a prospective data set.Setting Tertiary referral center.Patients Sea view at Palma de Mallorca [About the Cover] Archives of Otolaryngology Head & Neck Surgery: July 1, 2010, 12:00 pm About This Journal [About This Journal] Archives of Otolaryngology Head & Neck Surgery: July 1, 2010, 12:00 pm Lack of Financial Barriers to Pediatric Cochlear Implantation: Impact of Socioeconomic Status on Access and Outcomes [Original Article] Archives of Otolaryngology Head & Neck Surgery: July 1, 2010, 12:00 pm Objectives (1) To analyze if socioeconomic status influences access to cochlear implantation in an environment with adequate Medicaid reimbursement. (2) To determine the impact of socioeconomic status on outcomes after unilateral cochlear Propranolol in the Management of Airway Infantile Hemangiomas [Original Article] Archives of Otolaryngology Head & Neck Surgery: July 1, 2010, 12:00 pm Objective To report our experience with propranolol in managing airway infantile hemangiomas. Design Case series of 3 consecutive patients who had extensive, symptomatic airway infantile hemangiomas treated with propranolol. Setting Tertiary academic medical center. Patients
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